We concluded that BIS is valid for between-subject comparisons of body fluid compartments, is appropriate in clinical settings where change in ECV/ICV ratio is important, and should be used by comparing the required level of accuracy to the inherent technique error/variance. The correlation coefficients of dilution versus BIS volumes (r = 0.93 to 0.96) were significant at P < 0.0001 SEEs were: TBW, 2.23 L ECV, 1.26 L and ICV, 1.71 L. Extracellular fluid (ECF) surrounds all cells in the body. Cytosol The fluid containing nutrients, proteins, and other molecules in a cell, also called intracellular fluid. The intracellular fluid (ICF) compartment is the system that includes all fluid enclosed in cells by their plasma membranes. Dilution measures (TBW, 51.00 +/- 9.30 ECV, 19.88 +/- 3.14 ICV, 31.12 +/- 6.80 L) and BIS volumes (TBW, 50.03 +/- 7.67 ECV, 20.95 +/- 3.33 ICV, 29.04 +/- 4.51 L) were significantly different for ECV (P < 0.01) and ICV (P < 0.05) some individual differences were large. Related Biology Terms Extracellular Fluid Fluid that surrounds the cells of the body, but is separated still from the environment. In fact, intracellular fluid accounts for 60 of the volume of body fluids and 40 of a persons total body weight Extracellular fluids (ECF) are fluids found. Electrode placement, posture, exercise, food/fluid intake, and ambient temperature were controlled. Impedance was measured (50-500 kHz) at rest, on a nonconducting surface, with a BIS analyzer. The total water composition in the human body constitutes 67 of intracellular fluid and 26 of extracellular fluid. Blood plasma has high concentrations of sodium, chloride, bicarbonate, and protein. Thirteen healthy males (mean +/- SD: age, 23 +/- 3 yr body mass, 80.6 +/- 14.7 kg) had their TBW and ECV measured by ingesting dilution tracers (7.27 g deuterium oxide, 1.70 g sodium bromide blood samples at 0 and 4 h). The fluid that is present inside the cells is called intracellular fluid. The compositions of the two components of the extracellular fluidplasma and interstitial fluidare more similar to each other than either is to the intracellular fluid (Figure 3). The purpose of this study was to test the validity of a multiple frequency bioimpedance spectroscopy (BIS) technique that estimates extracellular fluid volume (ECV), intracellular fluid volume (ICV), and total body water (TBW). Intrinsic factors that dictate the movement of crystalloid fluids into individual body fluid compartments (intracellular, interstitial, intravascular) include the normal distribution of total body water, and the factors involved with the movement of fluids across the capillary membrane (e.g., transmembrane hydrostatic, colloid osmotic pressure.
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